Biomedical Anaesthesia

Conferences

Groups

EPSRC Grants

  • Adaptive Predictive Control of Anaesthesia via a Closed Circuit for Volatile Agents
    EPSRC Grant Reference: GR/L89051/01
    Dr M Mahfouf (University of Sheffield)
     
  • Development of an Adaptive Fuzzy Advisory System for Drug Delivery to Patients Undergoing Cardio-ByPass Surgery 
    EPSRC Grant Reference: GR/S94636/01
    Dr M Mahfouf (University of Sheffield)
     

Journals

Companies

  • Aspect Medical Systems
    http://www.aspectms.com/ 
    Patents US06338713 - System and method for adaptive drug delivery (ROC)
     

Researchers

Project

Misc.

Papers

Key References (need sorting !!)

  • Intravenous Drug-Delivery Systems - Toward an Intravenous Vaporizer
    Egan, T.D.
    Journal of Clinical Anesthesia, 1996. 8(S3): p. S 8-S 14.
     
  • Monitoring Depth of Anesthesia
    Stanski, D.R.
    Anesthesia. 1994. p. 1127-1159.
     
  • Measuring the Performance of Anesthetic Depth Indicators
    Smith, W.D., R.C. Dutton, and N.T. Smith
    Anesthesiology, 1996. 84(1): p. 38-51.
     
  • Analysis of the EEG bispectrum, auditory evoked potentials and the EEG power spectrum during repeated transitions from consciousness to unconsciousness. 
    Gajraj, R.J., M. Doi, H. Mantzaridis, and G.N.C. Kenny
    British Journal of Anaesthesia, 1998. 80(1): p. 46-52.
     
  • Relationship between calculated blood concentration of propofol and electrophysiological variables during emergence from anaesthesia: Comparison of bispectral index, spectral edge frequency, median frequency and auditory evoked potential index. 
    Doi, M., R.J. Gajraj, H. Mantzaridis, and G.N.C. Kenny
    British Journal of Anaesthesia, 1997. 78(2): p. 180-184.
     
  • Intravenous Drug Delivery Systems
    Glass, P.S.A., S.L. Shafer, J.R. Jacobs, and J.G. Reves
    Anesthesia. 1994. p. 389-416.
     
  • Performance of Computer-Controlled Infusion of Propofol - an Evaluation of 5 Pharmacokinetic Parameter Sets.
    Vuyk, J., F.H.M. Engbers, A.G.L. Burm, A.A. Vletter, and J.G. Bovill
    Anesthesia and Analgesia, 1995. 81(6): p. 1275-1282.
     
  • Levy, G., Predicting effective drug concentrations for individual patients - Determinants of pharmacodynamic variability. Clinical Pharmacokinetics, 1998. 34(4): p. 323-333.
  • Vuyk, J., Pharmacokinetic and pharmacodynamic interactions between opioids and propofol. Journal of Clinical Anesthesia, 1997. 9(S6): p. S23-S26.
  • Bailey, J.M. and S.L. Shafer, A Simple Analytical Solution to the 3-Compartment Pharmacokinetic Model Suitable For Computer-Controlled Infusion Pumps. IEEE Transactions On Biomedical Engineering, 1991. 38(6): p. 522-525.
     
  • Algorithms to Rapidly Achieve and Maintain Stable Drug Concentrations At the Site of Drug Effect With a Computer-Controlled Infusion Pump.
    Shafer, S.L. and K.M. Gregg
    Journal of Pharmacokinetics and Biopharmaceutics, 1992. 20(2): p. 147-169.
     
  • Development of the technology for 'Diprifusor' TCI systems
    Gray, J.M. and G.N.C. Kenny
    Anaesthesia, 1998. 53(S1): p. 22-27.
     
  • Closed-Loop Feedback-Control of Methohexital Anesthesia By Quantitative EEG Analysis in Humans
    Schwilden, H., J. Schuttler, and H. Stoeckel, 
    Anesthesiology, 1987. 67(3): p. 341-347.
     
  • Kenny, G.N.C., W. McFadzean, H. Mantzaridis, and A.C. Fisher, Closed-Loop Control of Anesthesia. Anesthesiology, 1992. 77(3A): p. A328-A328.
     
  • Linkens, D.A., J.S. Shieh, and J.E. Peacock, Hierarchical Fuzzy Modeling For Monitoring Depth of Anesthesia. Fuzzy Sets and Systems, 1996. 79(1): p. 43-57. 
     
  • Linkens, D.A., M.F. Abbod, and J.K. Backory, Closed-loop control of depth of anaesthesia: A simulation study using auditory evoked responses. Control Engineering Practice, 1997. 5(12): p. 1717-1726.
  • Short, T.G., P. Mainland, and J. Derrick. A Comparison of Manual Control and Closed-Loop Feedback Control of Propofol-Alfentanil Anesthesia Using the Bispectral Index as the Target. in SIVA Annual Meeting. 1996. New Orleans, USA.18. Webb, A., R. Allen, and D. Smith, Closed-loop control of depth of anaesthesia. Measurement & Control, 1996. 29(7): p. 211-215.
  • Roy, R.J. and J.W. Huang, Closed loop intravenous anesthetic administration. Anesthesiology, 1997. 87(3 SS): p. A461-A461.
  • Mortier, E., M. Struys, T. DeSmet, L. Versichelen, and G. Rolly, Closed loop controlled administration of propofol using bispectral analysis. Anaesthesia, 1998. 53(8): p. 749-754.
  • Epstein, R.H. Closed Loop Control of Hypnosis Using the Bispectral Index (BIS). in 18th International Symposium on Computing in Anesthesia and Intensive Care. 1998. Hamamatsu, Japan.22. Glen, J.B., The development of 'Diprifusor': a TCI system for propofol. Anaesthesia, 1998. 53(S1): p. 13-21.
  •  Jacobs, J.R., Algorithm For Optimal Linear Model-Based Control With Application to Pharmacokinetic Model-Driven Drug Delivery. IEEE Transactions On Biomedical Engineering, 1990. 37(1): p. 107-109 
     
  • Algorithm to Control Effect Compartment Drug Concentrations in Pharmacokinetic Model-Driven Drug-Delivery
    Jacobs, J.R. and E.A. Williams
    IEEE Transactions On Biomedical Engineering, 1993. 40(10): p. 993-999. 
     
  • Infusion Rate Control Algorithms For Pharmacokinetic Model-Driven Drug Infusion Devices
    Jacobs, J.R.
    International Anesthesiology Clinics, 1995. 33(3): p. 65-82.
     
  • Computer-Assisted Continuous Infusions of Fentanyl During Cardiac Anesthesia - Comparison With a Manual Method
    Alvis, J.M., J.G. Reves, A.V. Govier, P.G. Menkhaus, C.E. Henling, J.A. Spain, and E. Bradley
    Anesthesiology, 1985. 63(1): p. 41-49.
     
  • Manual Vs Target-Controlled Propofol Infusion - a Comparison of the Quality of Anesthesia Achieved By the Infusion of Propofol Using Manual or Target-Controlled Systems. 
    Russell, D., M.P. Wilkes, J.B. Glen, P. Hutton, and G.N.C. Kenny
    British Journal of Anaesthesia, 1995. 74(S1): p. 84-84.
     
  • Manual Compared With Target-Controlled Infusion of Propofol. 
    Russell, D., M.P. Wilkes, S.C. Hunter, J.B. Glen, P. Hutton, and G.N.C. Kenny, 
    British Journal of Anaesthesia, 1995. 75(5): p. 562-566.
     
  • Intravenous anaesthesia: manual infusion schemes versus TCI systems. 
    Russell, D.
    Anaesthesia, 1998. 53(S1): p. 42-45.
     
  • TCI compared with manually controlled infusion of propofol: a multicentre study 
    Servin, F.S.
    Anaesthesia, 1998. 53(S1): p. 82-86.
     
  • A Controller For Regulation of Mean Arterial Blood-Pressure Using Optimum Nitroprusside Infusion Rate.
    Behbehani, K. and R.R. Cross
    IEEE Transactions On Biomedical Engineering, 1991. 38(6): p. 513-521.
     
  • Adaptive control of arterial blood pressure with a learning controller based on multilayer neural networks
    Chen, C.T., W.L. Lin, T.S. Kuo, and C.Y. Wang
    IEEE Transactions On Biomedical Engineering, 1997. 44(7): p. 601-609.
     
  • Regulation of Glucose-Turnover and Hormonal Responses During Electrical Cycling in Tetraplegic Humans. 
    Kjaer, M., S.F. Pollack, T. Mohr, H. Weiss, G.W. Gleim, F.W. Bach, T. Nicolaisen, H. Galbo, and K.T. Ragnarsson
    American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 1996. 40(1): p. R 191-R 199.
     
  • A Robust Controller For Insulin Pumps Based On H-Infinity Theory. 
    Kienitz, K.H. and T. Yoneyama
    IEEE Transactions On Biomedical Engineering, 1993. 40(11): p. 1133-1137.
     
  • Self-Tuning PID Control of Atracurium-Induced Muscle-Relaxation in Surgical Patients. 
    Denai, M., D.A. Linkens, A.J. Asbury, A.D. Macleod, and W.M. Gray
    IEE Proceedings-D Control Theory and Applications, 1990. 137(5): p. 261-272.
     
  • Control Strategies For Nonlinear Dynamics of Muscle-Relaxant Anesthesia
    Linkens, D.A. and M. Khelfa
    Computer Methods and Programs in Biomedicine, 1992. 37(1): p. 1-30. 
     
  • Linkens, D.A. and S.B. Hasnain, Self-Organizing Fuzzy-Logic Control and Application to Muscle- Relaxant Anesthesia. IEE Proceedings-D Control Theory and Applications, 1991. 138(3): p. 274-284. 
  • Vishnoi, R. and R.J. Roy, Adaptive-Control of Closed-Circuit Anesthesia. IEEE Transactions On Biomedical Engineering, 1991. 38(1): p. 39-47.39. Jee, G.I. and R.J. Roy, Adaptive-Control of Multiplexed Closed-Circuit Anesthesia. IEEE Transactions On Biomedical Engineering, 1992. 39(10): p. 1071-1080.40. Sharma, A., R.L. Griffith, and R.J. Roy, An Adaptive Controller For the Administration of Closed-Circuit Anesthesia During Spontaneous and Assisted Ventilation. Journal of Clinical Monitoring, 1993. 9(1): p. 25-30.
  • Verkaaik, A.P.K. and G. Vandijk, High-Flow Closed-Circuit Anesthesia. Anaesthesia and Intensive Care, 1994. 22(4): p. 426-434. 
     
  • A System Model For Halothane Closed-Circuit Anesthesia - Structure Considerations and Performance Evaluation. 
    Vermeulen, P.M., J.G.C. Lerou, R. Dirksen, L. Booij, and G.F. Borm
    Anesthesiology, 1995. 83(3): p. 515-527.
     
  • Bickford, R.G., Automatic electroencephalographic control of general anesthesia. Electroencephalography and Clinical Neurophysiology, 1950. 2: p. 93-96.44. Bickford, R.G., Use of frequency discrimination in the automatic electroencephalographic control of anesthesia (servo-anesthesia). Electroencephalography and Clinical Neurophysiology, 1951. 3: p. 83-86.45. Bellville, J.W.A., G.M., Servo control of general anesthesia. Science, 1957. 126: p. 827-830.46. Schwilden, H., H. Stoeckel, and J. Schuttler, Closed-Loop Feedback-Control of Propofol Anesthesia By Quantitative EEG Analysis in Humans. British Journal of Anaesthesia, 1989. 62(3): p. 290-296.
     
  • Schwilden, H. and H. Stoeckel, Effective Therapeutic Infusions Produced By Closed-Loop Feedback- Control of Methohexital Administration During Total Intravenous Anesthesia With Fentanyl. Anesthesiology, 1990. 73(2): p. 225-229.48. Olkkola, K.T. and H. Schwilden, Quantitation of the Interaction Between Atracurium and Succinylcholine Using Closed-Loop Feedback-Control of Infusion of Atracurium. Anesthesiology, 1990. 73(4): p. 614-618.
     
  • Adaptive Closed-Loop Feedback-Control of Vecuronium-Induced Neuromuscular Relaxation
    Olkkola, K.T. and H. Schwilden
    European Journal of Anaesthesiology, 1991. 8(1): p. 7-12.
     
  • Model-Based Adaptive Closed-Loop Feedback-Control of Atracurium- Induced Neuromuscular Blockade
    Olkkola, K.T., H. Schwilden, and C. Apffelstaedt
    Acta Anaesthesiologica Scandinavica, 1991. 35(5): p. 420-423.
     
  • Schwilden, H. and H. Stoeckel, Closed-Loop Feedback Controlled Administration of Alfentanil During Alfentanil Nitrous-Oxide Anesthesia. British Journal of Anaesthesia, 1993. 70(4): p. 389-393.52. Albrecht, S., H. Ihmsen, K. Suchodolski, K. Rommelsheim, and J. Schuttler, Long-term ICU sedation with an EEG controlled closed-loop system. Anesthesiology, 1997. 87(3 SS): p. A221-A221.53. Schuttler, J., H. Ihmsen, C. Frenkel, M. Fischer, F. Bremer, J. Kalff, and A. Hirner, Pharmacokinetics of Propofol and Alfentanil During Liver- Transplantation With Eeg-Controlled Closed-Loop Total Intravenous Anesthesia. Anesthesiology, 1995. 83(3A SS): p. A 373-A 373.54. Kenny, G.N.C., W. McFadzcan, H. Mantzaridis, and A.C. Fisher, Propofol Requirements During Closed-Loop Anesthesia. Anesthesiology, 1993. 79(3A SS): p. A 329-A 329.55. Kenny, G.N.C., Software Safety Considerations in the Use of Closed-Loop, Patient- Connected Control-Systems. British Journal of Anaesthesia, 1993. 71(3): p. 462-462.56. Kenny, G.N.C., F.W. Davies, H. Mantzaridis, and A.C. Fisher, Transition Between Consciousness and Unconsciousness During Anesthesia. Anesthesiology, 1993. 79(3A SS): p. A 330-A 330.57. Huang, J.W., Y.Y. Lu, and A. Nayak, Depth of Anesthesia Estimating & Propofol Delivery System. http://www.rpi.edu/~royr/roy_descpt.html#proptrol, 1996.58. Shafer, S., STANPUMP, . 1996, PKPD Software Server, http://pkpd.icon.palo-alto.med.va.gov/: Stanford, USA.59. Liu, J., G. Wu, H. Singh, G.Y. Gaines, and P.F. White, Use of EEG Bispectral Analysis For Assessing Depth of Sedation. Anesthesiology, 1993. 79(3A SS): p. A 455-A 455.60. Liu, J., G. Wu, H. Singh, G.Y. Gaines, and P.F. White, Optimal EEG Index For Monitoring Depth of Sedation. Anesthesia and Analgesia, 1994. 78(2 SS): p. U 141-U 141.61. Kearse, L., C. Rosow, P. Sebel, M. Bloom, P. Glass, S. Howell, and S. Greenwald, The Bispectral Index Correlates With Sedation Hypnosis and Recall - Comparison Using Multiple Agents. Anesthesiology, 1995. 83(3A SS): p. A 507-A 507.62. Liu, J., H. Singh, G. Wu, and P.F. White, EEG Bispectral Analysis Predicts Depth of Sedation and Amnesia. Anesthesiology, 1995. 83(3A SS): p. A 504-A 504.63. Leslie, K., D.I. Sessler, M. Schroeder, and K. Walters, The Bispectral Index Is Linearly Related to Propofol Blood- Concentration. Anesthesiology, 1995. 83(3A SS): p. A 194-A 194.64. Pearson, A.J., C.J.D. Pomfrett, B.R.H. Doran, and B.J. Pollard, Evaluation of Bispectral Index As an Objective Sedation Score in the Intensive-Care Unit. British Journal of Anaesthesia, 1996. 76(4): p. 577-P 578.65. Jopling, M.W. and J.C. Sigl, The EEG Bispectral Index and Autonomic Responses Under General- Anesthesia. Anesthesia and Analgesia, 1996. 82(4 SS): p. SCA74-SCA74.66. Sebel, P.S., E. Lang, I.J. Rampil, P.F. White, R. Cork, M. Jopling, N.T. Smith, P.S.A. Glass, and P. Manberg, A multicenter study of bispectral electroencephalogram analysis for monitoring anesthetic effect. Anesthesia and Analgesia, 1997. 84(4): p. 891-899.67. Hu, C.P., W.S. Lovejoy, and S.L. Shafer, Comparison of Some Control Strategies For 3-Compartment PK/PD Models. Journal of Pharmacokinetics and Biopharmaceutics, 1994. 22(6): p. 525-550.68. Isaka, S. and A.V. Sebald, Control Strategies For Arterial Blood-Pressure Regulation. IEEE Transactions On Biomedical Engineering, 1993. 40(4): p. 353-363.69. Vanlandingham, H.F., Introduvtion to Digital Control Systems. 1985, New York: Macmillan Publishing Company. 460.70. Thornton, C. and D.E.F. Newton, The Auditory Evoked Response: A Measure of Depth of Anaesthesia, in Balilliere's Clinical Anaesthesiology, J.G. Jones, Editor. 1989, Balilliere Tindall. p. 559-586.71. Glass, P.S.A., D. Doherty, J.R. Jacobs, and T.J. Quill, Pharmacokinetic Basis of Intravenous Drug Delivery. Baillieres Clinical Anaesthesiology, 1991. 5(3): p. 735-775.72. Jacobs, J.R., Analytical Solution to the 3-Compartment Pharmacokinetic Model. IEEE Transactions On Biomedical Engineering, 1988. 35(9): p. 763-765.
     
  • Ausems, M.E., D.R. Stanski, and C.C. Hug, An Evaluation of the Accuracy of Pharmacokinetic Data For the Computer-Assisted Infusion of Alfentanil. British Journal of Anaesthesia, 1985. 57(12): p. 1217-1225.74. Maitre, P.O., M.E. Ausems, S. Vozeh, and D.R. Stanski, Evaluating the Accuracy of Using Population Pharmacokinetic Data to Predict Plasma-Concentrations of Alfentanil. Anesthesiology, 1988. 68(1): p. 59-67.75. Varvel, J.R., D.L. Donoho, and S.L. Shafer, Measuring the Predictive Performance of Computer-Controlled Infusion Pumps. Journal of Pharmacokinetics and Biopharmaceutics, 1992. 20(1): p. 63-94.76. Short, T.G., Y.H. Tam, P. Tan, and T.E. Oh, Pharmacokinetic Model-Controlled Infusion of Midazolam - a Prospective Evaluation During General-Anesthesia. Anaesthesia, 1993. 48(3): p. 187-191.
     
  • Short, T.G., C.S.T. Aun, P. Tan, J. Wong, Y.H. Tam, and T.E. Oh, A Prospective Evaluation of Pharmacokinetic Model Controlled Infusion of Propofol in Pediatric-Patients. British Journal of Anaesthesia, 1994. 72(3): p. 302-306.78. Maitre, P.O., M.E. Ausems, S. Vozeh, D.A. Thomson, and D.R. Stanski, Applying Alfentanil Population Pharmacokinetics to Predict Perioperative Plasma-Concentrations. Anesthesiology, 1986. 65(3A): p. A226-A226.79. Maitre, P.O., S. Vozeh, J. Heykants, D.A. Thomson, and D.R. Stanski, Population Pharmacokinetics of Alfentanil - the Average Dose-Plasma Concentration Relationship and Interindividual Variability in Patients. Anesthesiology, 1987. 66(1): p. 3-12.80. Maitre, P.O., M. Buhrer, D.R. Stanski, and D. Thomson, A 3 Step Population Pharmacokinetic Analysis Using Nonmem and Bayesian Regression. Clinical Pharmacology and Therapeutics, 1989. 45(2): p. 129-129.81. Stanski, D.R. and P.O. Maitre, Population Pharmacokinetics and Pharmacodynamics of Thiopental - the Effect of Age Revisited. Anesthesiology, 1990. 72(3): p. 412-422.82. Vozeh, S., P.O. Maitre, and D.R. Stanski, Evaluation of Population (Nonmem) Pharmacokinetic Parameter Estimates. Journal of Pharmacokinetics and Biopharmaceutics, 1990. 18(2): p. 161-173.83. Maitre, P.O., M. Buhrer, D. Thomson, and D.R. Stanski, A 3-Step Approach Combining Bayesian Regression and Nonmem Population Analysis - Application to Midazolam. Journal of Pharmacokinetics and Biopharmaceutics, 1991. 19(4): p. 377-384.84. Mandema, J.W., C. Hu, P.L. Gambus, J. Barr, and S.L. Shafer, Population Pharmacodynamics of Propofol For ICU Sedation. Clinical Pharmacology & Therapeutics, 1995. 57(2): p. 156-156.85. Minto, C.F., T.W. Schnider, T.D. Egan, E. Youngs, H.J.M. Lemmens, P.L. Gambus, V. Billard, J.F. Hoke, K.H.P. Moore, D.J. Hermann, K.T. Muir, J.W. Mandema, and S.L. Shafer, Influence of age and gender on the pharmacokinetics and pharmacodynamics of remifentanil .1. Model development. Anesthesiology, 1997. 86(1): p. 10-23.86. Wright, P.M.C., Population based pharmacokinetic analysis: why do we need it; what is it; and what has it told us about anaesthetics? British Journal of Anaesthesia, 1998. 80(4): p. 488-501.87. Wada, D.R. and D.S. Ward, The Hybrid Model - a New Pharmacokinetic Model For Computer- Controlled Infusion Pumps. IEEE Transactions On Biomedical Engineering, 1994. 41(2): p. 134-142.88. Wada, D.R. and D.S. Ward, Open-Loop Control of Multiple-Drug Effects in Anesthesia. IEEE Transactions On Biomedical Engineering, 1995. 42(7): p. 666-677.
     
  • Cammarota, J.P. and B. Onaral, State transitions in physiologic systems: A complexity model for loss of consciousness. IEEE Transactions On Biomedical Engineering, 1998. 45(8): p. 1017-1023.90. Plummer, J.L. and T.G. Short, Analysis of Effects of Drug-Combinations. British Journal of Anaesthesia, 1992. 68(1): p. 114-114.91. Vinik, H.R., Intravenous Anesthetic Drug-Interactions - Practical Applications. European Journal of Anaesthesiology, 1995. 12(S12): p. 13-19.92. Stanski, D.R. and S.L. Shafer, Quantifying Anesthetic Drug-Interaction - Implications For Drug Dosing. Anesthesiology, 1995. 83(1): p. 1-5.93. Hu, C., S. Greenwald, N. Chamoun, and S.L. Shafer, Predicting anesthetic depth using EEG and models of drug interaction. Clinical Pharmacology & Therapeutics, 1997. 61(2): p. II45-PII45.94. Rosow, C.E., Anesthetic drug interaction: An overview. Journal of Clinical Anesthesia, 1997. 9(S6): p. S27-S32.95. Dawson, J. and L. Karalliedde, Drug interactions and the clinical anaesthetist. European Journal of Anaesthesiology, 1998. 15(2): p. 172-189.96. Vuyk, J., TCI: supplementation and drug interactions. Anaesthesia, 1998. 53(S1): p. 35-41.97. Schwilden, H., Use of the Median EEG Frequency and Pharmacokinetics in Determining Depth of Anesthesia. Baillieres Clinical Anaesthesiology, 1989. 3(3): p. 603-621.
  • Schwilden, H. and J. Schuttler, Determination of Effective Therapeutic Infusion Rates For Intravenous Anesthetic Agents With Feedback-Controlled Dosing. Anaesthesist, 1990. 39(11): p. 603-606.
     
  • Use of a Pharmacokinetic-Dynamic Model For the Automatic Feedback- Control of Atracurium
    Schwilden, H. and K.T. Olkkola, 
    European Journal of Clinical Pharmacology, 1991. 40(3): p. 293-296.
     
  • Hemmerling, T. and H. Schwilden, Determination of the effective therapeutic infusions (ETI) of cis- atracurium during isoflurane or propofol/alfentanil anesthesia by closed-loop feedback control. Anesthesiology, 1997. 87(3 SS): p. A843-A843.
  • Schraag, S., U. Mohl, U. Bothner, and M. Georgieff, Clinical utility of EEG parameters to predict loss of consciousness and response to skin incision during total intravenous anaesthesia. Anaesthesia, 1998. 53(4): p. 320-325.
  • Gajraj, R.J., M. Doi, and G.N.C. Kenny, Comparison of Bisectral EEG Analysis with Auditory Evoked Potentials in Spontaneously Breathing Anaesthetised Patients. SCATA News, 1996. 5(2): p. 9.
     
  • Bispectrum Estimation - a Digital Signal-Processing Framework
    Nikias, C.L. and M.R. Raghuveer
    Proceedings of the IEEE, 1987. 75(7): p. 869-891
     
  • Vernon, J.M., E. Lang, P.S. Sebel, and P. Manberg, Prediction of Movement Using Bispectral Electroencephalographic Analysis During Propofol Alfentanil or Isoflurane Alfentanil Anesthesia. Anesthesia and Analgesia, 1995. 80(4): p. 780-785.105. 
     
  • Bispectral Analysis of the Electroencephalogram Correlates With Patient Movement to Skin Incision During Propofol Nitrous-Oxide Anesthesia. Kearse, L.A., P. Manberg, N. Chamoun, F. Debros, and A. Zaslavsky
    Anesthesiology, 1994. 81(6): p. 1365-1370 
     
  • Bispectral Analysis of the Electroencephalogram During Induction of Anesthesia May Predict Hemodynamic-Responses to Laryngoscopy and Intubation. 
    Kearse, L.A., P. Manberg, F. Debros, N. Chamoun, and V. Sinai
    Electroencephalography and Clinical Neurophysiology, 1994. 90(3): p. 194-200. 
  • Liu, J., H. Singh, and P.F. White, Use of EEG Bispectral Index to Predict the Depth of Sedation and Amnesia With Propofol and Midazolam. Anesthesiology, 1995. 83(3A SS): p. A 124-A 124.
     
  • Electroencephalogram Bispectral Analysis Predicts the Depth of Midazolam-Induced Sedation
    Liu, J., H. Singh, and P.F. White
    Anesthesiology, 1996. 84(1): p. 64-69.
     
  • Electroencephalographic bispectral index correlates with intraoperative recall and depth of propofol-induced sedation
    Liu, J., H. Singh, and P.F. White
    Anesthesia and Analgesia, 1997. 84(1): p. 185-189. 
     
  • Bispectral Index As an EEG Measure of the Sedative Effect of Isoflurane
    Bloom, M.J., S. Whitehurst, M. Mandel, and R. Policare
    Anesthesiology, 1995. 83(3A SS): p. A 195-A 195. 
     
  • 111. Glass, P.S., M. Bloom, L. Kearse, C. Rosow, P. Sebel, and P. Manberg, Bispectral analysis measures sedation and memory effects of propofol, midazolam, isoflurane, and alfentanil in healthy volunteers. Anesthesiology, 1997. 86(4): p. 836-847.
     
  • Alkire, M.T., Quantitative EEG correlations with brain glucose metabolic rate during anesthesia in volunteers. Anesthesiology, 1998. 89(2): p. 323-333.113. Sebel, P.S. and J.D. Lowdon, Propofol - a New Intravenous Anesthetic. Anesthesiology, 1989. 71(2): p. 260-277.
  • Vuyk, J., M.J. Mertens, E. Olofsen, A.G.L. Burm, and J.G. Bovill, Propofol anesthesia and rational opioid selection - Determination of optimal EC50-EC95 propofol-opioid concentrations that assure adequate anesthesia and a rapid return of consciousness. Anesthesiology, 1997. 87(6): p. 1549-1562.
     
  • Sneyd, J.R., A. Carr, W.D. Byrom, and A.J.T. Bilski, A meta-analysis of nausea and vomiting following maintenance of anaesthesia with propofol or inhalational agents. European Journal of Anaesthesiology, 1998. 15(4): p. 433-445.
     
  • Gepts, E., F. Camu, I.D. Cockshott, and E.J. Douglas, Disposition of Propofol Administered As Constant Rate Intravenous Infusions in Humans. Anesthesia and Analgesia, 1987. 66(12): p. 1256-1263.
     
  • Accuracy of PK model driven infusion of propofol
    Glass, P.
    Anesthesiology, 1989. 71: p. A277.
     
  • Pharmacokinetic Model Selection For Target Controlled Infusions of Propofol - Assessment of 3 Parameter Sets
    Coetzee, J.F., J.B. Glen, C.A. Wium, and L. Boshoff
    Anesthesiology, 1995. 82(6): p. 1328-1345.
     
  • Pharmacokinetics of Propofol During and After IV Infusion in Man
    Cockshott, I.D., E.J. Douglas, C. Prysroberts, M. Turtle, and D.P. Coates
    British Journal of Anaesthesia, 1987. 59(7): p. 941-P942.
     
  • Computer-Controlled Infusion of Propofol
    Tackley, R.M., G.T.R. Lewis, C. Prysroberts, R.W. Boaden, J. Dixon, and J.T. Harvey
    British Journal of Anaesthesia, 1989. 62(1): p. 46-53. 
     
  • Pharmacokinetics and Pharmacodynamics of Propofol Infusions During General-Anesthesia
    Shafer, A., V.A. Doze, S.L. Shafer, and P.F. White
    Anesthesiology, 1988. 69(3): p. 348-356.
     
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    Marsh, B., M. White, N. Morton, and G.N.C. Kenny
    British Journal of Anaesthesia, 1991. 67(1): p. 41-48.
     
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    Shafer, S.L., L.C. Siegel, J.E. Cooke, and J.C. Scott
    Anesthesiology, 1988. 68(2): p. 261-266.
     
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    Anaesthetic Research Society. 1998. UK: British Journal of Anaesthesia
     

2005 - SPMC / SoCCE / UoP