Research Staff
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Dr Chao Dong
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Project
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Closed-loop control of total intravenous anaesthesia
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Director of Studies
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Professor Emmanuel Ifeachor
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Supervisors
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Professor Robert Sneyd and Dr Christopher Reeve
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Email
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Research Project
Fully automated, closed loop computer control is a technique that may, in the future, enable both sedation and anaesthesia to be controlled with greater precision and in a less operator dependent manner. Potentially, this would assist anaesthetists to improve the quality of patient care and reduce costs, but their use as a routine clinical tool awaits evidence that they are safe and useful. The main aim of this project is to investigate the possibility of using a closed-loop system, based on biosignals analysis, for safe and reliable delivery of total intravenous anaesthesia. A close loop computer controlled system for anaesthesia/sedation has been designed, constructed and tested and has proved satisfactory when used to control sedation in volunteers. The system uses an EEG derivative, the Bispectral Index (BIS), as the feedback signal. It comprises an EEG monitor (Aspect A1000), a computer based control system incorporating an advanced software controller and a pharmacokinetic and pharmacodynamic model which controls the infusion of the sedative/anaesthetic agent propofol by a Graseby 3400 infusion pump. The performance of the system is being evaluated in clinical studies with ethical approval (e.g. on patients undergoing surgery) to provide experience in its use in clinical practice.
Publications
Using simulations in the design of an anaesthesia system.
Sneyd J. R., Dong C., Reeve C. D. and Ifeachor E. C.
Simulation and Gaming, 2001. Vol. 32, No. 2, pp. 205-214.
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Does nitrous oxide affect closed-loop anaesthesia
Dong C., Kehoe, J., Ifeachor E. C., Reeve, C. D., Sneyd, J. R.
British Journal of Anaesthesia, 1999, September, Vol. 83, p. 516.
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Closed-loop anaesthesia during knee surgery under epidural
anaesthesia.
Dong C., Wrigley, S. R., Ifeachor E. C., Reeve, C. D., Sneyd, J. R.
British Journal of Anaesthesia, 1999, September, Vol. 83, pp.
516-517.
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Closed loop computer controlled sedation with propofol
Dong C., Kehoe J., Henry J., Ifeachor E. C., Reeve C. D. and Sneyd, J. R.
British Journal Anaesthesia, p. 631.
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Misc.
Anaesthesia
Research Links
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